When my partner and I started trying to conceive, I knew that maintaining a healthy weight could increase my chances of success. But for me, with polycystic ovarian syndrome (PCOS), both boosting my chances of conception and managing my weight have always been uphill battles. I’ve tried to keep myself informed, but the internet is full of conflicting advice, especially when it comes to supplements like inositol. I kept reading about how it could help with PCOS and insulin resistance, but then I stumbled on claims that inositol can cause weight gain, and the last thing I wanted was to make things worse.
I decided to dig deeper into the research to understand whether inositol can cause weight loss or weight gain, and whether it could be the right choice for me. What I found was that it’s actually more likely to have the opposite effect and potentially help with weight loss due to improved insulin sensitivity. Let’s have a deeper look at it.
What does inositol do in the body?
Inositol is a naturally occurring sugar that plays a key role in hormone signaling, chemical balance, cell growth, and other biological processes. There are several forms of inositol in the body, but the most common are myo-inositol (MI) and d-chiro-inositol (DCI). These two forms are particularly important for the absorption, metabolism, and storage of glucose. Due to this connection with glucose regulation, inositol is often used as a supplement for managing conditions such as polycystic ovary syndrome (PCOS), metabolic syndrome, gestational diabetes, and others. Inositol is present in certain foods and is also available as a dietary supplement.
What does weight have to do with fertility?
Many overweight women experience successful and healthy pregnancies. Losing weight is not always necessary to conceive, but it may be helpful in some cases. Ovulation is most likely to occur in people with a healthy weight. Being severely underweight or overweight can lead to challenges such as anovulation or irregular menstrual cycles. Women who are overweight or obese also face an increased risk of miscarriage and pregnancy complications.
Individuals who are overweight or obese and looking to reduce the risk of infertility or pregnancy complications may benefit from weight loss to support reproductive health. Achieving weight loss through healthy methods is essential, as excessive exercise and inadequate nutrition can have harmful effects and may also lead to issues with menstruation and challenges with conception. Consulting a healthcare provider is recommended when making efforts to lose or gain weight, especially when the goal is to improve reproductive outcomes.
What is PCOS?
PCOS, or polycystic ovary syndrome, is an endocrine disorder that affects 7 – 10% of females of childbearing age in the United States. It is marked by various symptoms, including elevated levels of male hormones, the presence of multiple ovarian cysts, and irregular ovulation. Many individuals with PCOS and insulin resistance have difficulty for their body to use insulin effectively. Other common symptoms include acne, hair growth in areas typical of male patterns, thinning hair, irregular menstrual cycles, and a higher risk of obesity, diabetes, heart disease, and other health concerns. 
What is the connection between PCOS and weight?
Not all individuals with PCOS are overweight, nor do all overweight individuals have PCOS. However, research does indicate there is a strong correlation, with some studies estimating that approximately 80% of individuals in the United States with PCOS are classified as overweight or obese.
Weight gain and obesity can play a role in the development of PCOS through several different processes. One key factor in PCOS and insulin resistance is the way it affects metabolism and hormones, leading to issues with reproduction. Fat tissue, both under the skin and around organs, also produces substances that impact metabolism. PCOS is complex, so there are other factors that may come into play when trying to lose weight or keep it off, such as lower energy use, mental health struggles, or being less active physically.
Does inositol help with weight loss?
Weight loss usually requires more than just taking a supplement. However, research indicates that inositol can cause weight loss, reducing body mass index (BMI), improving ovarian function, and helping restore regular menstrual cycles.
Inositol’s potential impact on weight loss is believed to be connected to its positive effects on both PCOS and insulin sensitivity. Prolonged insulin resistance can cause the body to produce higher levels of insulin, which may lead to weight gain and further worsen the other aspects coming from PCOS and insulin resistance. This cycle is often observed in individuals with PCOS or those who are overweight or obese. Inositol supports the body by aiding in the absorption, storage, and metabolism of glucose, which can improve insulin sensitivity and contribute to weight loss. However, inositol alone is unlikely to result in significant weight loss and is most effective when combined with a healthy diet and regular exercise under the guidance of a healthcare provider.
Is metformin better than inositol for weight loss?
Metformin, an antidiabetic medication commonly used to manage type 2 diabetes, is also frequently prescribed for the treatment and prevention of PCOS. It helps lower blood glucose levels, decreases glucose production, and improves insulin sensitivity. Some studies have also explored its effects on weight loss in individuals with PCOS or diabetes. When comparing metformin to inositol for weight loss, research findings are mixed. Certain studies indicate little difference between the two, while others suggest metformin may be more effective for weight loss, with inositol offering benefits for ovarian health and cycle regularity.
Other tips to maintain a healthy weight
Healthy weight loss does not need to be drastic and may not always result in noticeable changes. Losing just 5% to 10% of total body weight can offer significant health benefits and may help improve symptoms of PCOS.
Rather than relying on unsustainable diets or extreme exercise routines, making small, manageable changes to daily habits can be more effective. For instance, increasing water consumption and unsweetened beverages while reducing soda or sugary drink intake is a simple adjustment. Regular physical activity, such as daily walks or attending workout classes a few times a week, can promote a healthier lifestyle. Over time, gradually increasing the duration of exercise or other active pursuits may yield better results. Limiting fast food and dining out, as well as reducing alcohol consumption, are additional ways to encourage healthier habits. If progress is slow or weight loss proves challenging, consulting a healthcare provider for further guidance is recommended.
Frequently Asked Questions
Why am I gaining weight with inositol?
There’s no solid proof that inositol can cause weight change. However, some individuals may experience gastrointestinal side effects such as bloating when taking the supplement.
What to avoid while taking inositol?
Inositol may help reduce blood sugar levels. When combined with diabetes medications, it could cause blood sugar to drop excessively. Be sure to monitor levels carefully.
Does inositol mess with hormones?
Inositol may help regulate hormone levels by improving insulin sensitivity. Additionally, as a second messenger, inositol can influence various hormones, including androgens and those critical for ovulation, like FSH.
When should I take inositol, morning or night?
For optimal weight loss results, try taking inositol in the morning to help manage blood sugar levels and control appetite throughout the day.
